Actives And Delivery Systems

Hyaluronic acid is a natural polysaccharide, widely distributed throughout connective, epithelial, and neural tissues. It is a major component of skin, where it is involved in moisturization and tissue repair.
Hyaoligo® - Low MW, high purity Sodium Hyaluronate, obtained via an enzymatic process. It promotes moisturization deep in the skin and help cell repair.
Hyacharming® - Sodium Hyaluronate dispersed in oil at 30% active. It brings natural moisturization to anhydrous formulas
HA Pro® - Acetylated Sodium Hyaluronat, a super moisturizer and free radical scavenger
HA-Zn - Zinc Hyaluronate. In addition to moisturization, it is a 5alpha-reductase and helps with skin oil control
Treme-HA® - Plant derived, high MW polysaccharide, highly efficient moisturizer and free radical scavenger

Peptides are chain-like molecules composed of 2 to 100 amino-acids linked by peptide bonds. They are characterized by high-bioactivity, target specificity, low allergenicity and skin penetration and interact with specific skin receptors to deliver multiple benefits. They trigger bio-responses from the cell, instead of initiating chemical reactions in the cell: typically dosed in ppm whereas actives require concentration levels in %. Peptides promote a precise and gentle approach because it taps into the skin own regulatory pathways.

Ceramides are a class of Sphingolipids composed of sphingosine and a fatty acid joined by an amide bond, widely present in biological membranes. They represent 50% of the stratum corneum composition. Ceramides are critical components for maintaining the skin barrier function. However, ceramide levels significantly drops after the age of 30: supplementation is needed to maintain the skin barrier functions.

Blends of peptides, ceramides and hyaluronates to enhance skin barrier support, collagen synthesis, deep hydration and skin elasticity and frimness through the synergistic action of the three components.

Liposomal formulations made with Phytopresome™ enhance the penetration of active in the epidermis, increase Stratum Corneum retention, promote sustained release and long-lasting effect and help formulate lipid-soluble actives in water-based formulas.
Phytopresome™ are liposome precursors composed of lecithin, phytosterol and an active, supplied as powder: the liposomal suspension needs to be made before the product is formulated.

Glycospheres are supramolecular systems, which consists of a stable inner core, made of starch, and lipids layers (fatty acid esters and polar lipids), organized around this core. The small size (200 nanometers) of this spherical system allows a controlled penetration in the first layers of the epidermis.
Both hydrophilic and lipopilic active ingredients can be entrapped in the Glycospheres. Experiments on ascorbic acid, free-radical scavengers, enzymes or antibacterial agents have shown that entrapped actives are more stable than the non-entrapped form, and remain active after entrapment and delivery.

Softspheres™ are large spherical (1.00 to 2.80 mm) particles used for the decoration of formulas and the delivery of lipophilic and / or anionic active ingredients. Made of agar-agar, they are soft enough for being crushed on the skin without leaving any residue. To this agar matrix a copolymer, cationic and amphiphilic is added, which is able to trap active material (natural oils, proteins, vitamins, fragrances, …) and colorants within the sphere.